Several months before the release of Uncharted 4: A Thief's End, Naughty Dog confirmed that Uncharted 4 would be the last game in the series to star Nathan Drake. Despite the announcement of Uncharted: The Lost Legacy, which features Chloe Frazer as the main character, and speculation that the series could go on without Nathan Drake, the studio admits that an Uncharted title after The Lost Legacy is unlikely.
"I would say that Naughty Dog doing an Uncharted after this is unlikely," Naughty Dog co-president Evan Wells told Game Informer. "I would never say never, but we've got The Last of Us Part II on our plates and there's so much other stuff that [we want to explore]. It'd be hard. If we magically had that two-team, three-team studio, sure --- it'd be great to keep doing it. We really love the franchise, but the studio has limited resources and lots of other ideas. I'd say the likelihood is low."
Uncharted: The Lost Legacy releases this year on PS4.
Source: Game Informer