BioWare have announced and confirmed that Mass Effect 3 will ship with Kinect support for the Xbox 360 version. They even demoed a whole level using voice commands.
Players can now select dialogue options simply by speaking it out. Players can also issue squad commands using voice control. For example, getting Liara to use her biotics or getting Mordin to take cover.
It's a simple extension of player control, but it looks pretty sweet. You know what they say, sometimes simple is best.